Clinical testing of pediatric mpox specimens: Unique features and challenges in a low prevalence populationArticle Published on 2023-06-012023-06-10 Journal: Journal of Clinical Virology [Category] Fulltext, 원숭이두창, [키워드] False positive Monkeypox virus mpox PCR pediatric. [DOI] 10.1016/j.jcv.2023.105447 PMC 바로가기
Analysis of diagnostic performance and factors causing nonspecific reactions in SARS-CoV-2 rapid antigen detection testsArticle Published on 2023-02-012023-07-10 Journal: Journal of infection and chemotherapy : official j [Category] COVID19(2023년), [키워드] detection False positive rapid antigen test SARS-CoV-2. [DOI] 10.1016/j.jiac.2022.10.007 PMC 바로가기
Association Between Maintenance Immunosuppressive Regimens and COVID-19 Mortality in Kidney Transplant RecipientsArticle Published on 2022-10-012022-11-15 Journal: Transplantation [Category] 진단, [키워드] age association baseline baseline characteristics cardiovascular disease cohort study Comorbidity conducted coronavirus disease Corticosteroid COVID-19 death diabete died evaluated False positive form French high risk hypertension immune function Immunosuppression immunosuppressive immunosuppressive drug impair inhibitor kidney transplant Logistic regression lower risk maintenance mammalian men Mortality MOST multiple imputation Odds ratio outcome p value performed Rapamycin recipient recipients regimen registry retrieved risk of death serum creatinine significantly lower Solid solid organ solid organ transplant statistically significant Transplant was used with COVID-19 [DOI] 10.1097/TP.0000000000004254 PMC 바로가기
SARS-CoV-2 Seroprevalence Study in Pediatric Patients and Health Care Workers Using Multiplex Antibody ImmunoassaysArticle Published on 2022-09-142022-11-15 Journal: Viruses [Category] SARS, 변종, 진단, 치료기술, [키워드] Adults affected antibody Antigen Beta children circulating Clinical characteristics Cohort correlation COVID-19 delta variant disease ELISA estimate exacerbated False positive Gamma group HCW Health healthcare healthcare worker Healthcare workers highlight hospitals IgA IgA response IgG IgM indicated Infection isotype lowest Luminex assay Mild nucleocapsid PIMS-TS positive correlation RBD recruited SARS-CoV-2 SARS-CoV-2 proteins sensitivity Seropositivity seropositivity. Seroprevalence significantly lower Spain Spanish specificity study period the receptor-binding domain variants were measured worker [DOI] 10.3390/v14092039 PMC 바로가기
Investigating the Sensitivity of Nasal or Throat Swabs: Combination of Both Swabs Increases the Sensitivity of SARS-CoV-2 Rapid Antigen TestsArticle Published on 2022-08-312022-11-15 Journal: Microbiology Spectrum [Category] COVID19(2023년), SARS, 변종, 진단, 치료기술, [키워드] Abbott Ag-RDT Ag-RDTs Anecdote Antigen Asymptomatic Asymptomatic individuals buffer cold-like symptoms Combination combined nasal/throat swab COVID-19 COVID-19 pandemic determine ENhance False positive false-positive result flexible IMPROVE increase Local media molecular nare nasal nasal swab omicron PanBio Panbio Ag-RDT positive predominant Rapid Rapid test response reverse transcriptase PCR RT-PCR SARS-CoV-2 SARS-CoV-2 detection sensitivity sore throat suggested Support Swab Test Throat throat swab throat. variants of concern [DOI] 10.1128/spectrum.00217-22 PMC 바로가기
Evaluation of Saliva as a Matrix for RT-PCR Analysis and Two Rapid Antigen Tests for the Detection of SARS-CoV-2Article Published on 2022-08-302022-11-15 Journal: Viruses [Category] SARS, 치료기술, [키워드] acute respiratory syndrome Antigen Characteristics collected coronavirus detection evaluate False positive individual individuals lack matrix nasopharyngeal Nasopharyngeal swab Negative predictive value NPV Patient performed polymerase chain positive Rapid rapid antigen test resulting RT-PCR Saliva Saliva. SARS-CoV-2 SARS-CoV-2 detection SARS-CoV-2 RT-PCR test screened sensitivity specificity Standardization Test thought Whistling [DOI] 10.3390/v14091931 PMC 바로가기
A randomised, double-blind, placebo-controlled, multicentre clinical trial of AZD1656 in diabetic patients hospitalised with COVID-19: The ARCADIA Trial – implications for therapeutic immune modulationResearch article Published on 2022-08-182022-10-05 Journal: EClinicalMedicine [Category] 바이오마커, 변종, 임상, [키워드] 1:1 Activation Adaptive immune response addition adverse event ARCADIA assigned AZD1656 Clinical improvement clinical trial Complete COVID-19 cytokine Czech Republic Day death decrease diabetes diabetic patient diabetic patients dose double-blind duration of hospitalisation Efficacy Excalibur False positive finding Full Analysis Set funding Glucokinase activator group homeostatic hospital hospital discharge hospitalised identify immune Immune cell immune modulation immune response Immunochemistry immunomodulatory effect Immunophenotyping implication indicated Innovation investigated involved less Medicine multicentre nine no difference Patient phase Phase 2 Placebo placebo-controlled placebo-controlled clinical trial primary analysis primary endpoint pro-inflammatory randomised Randomly receive recruited reduction in Registered regulatory T cells required risk Romania SARS-CoV-2 screened statistically significant difference suggested Tablet the placebo group therapeutic therapeutic effect treated Treatment treatment allocation Tregs Trial usual care with COVID-19 [DOI] 10.1016/j.eclinm.2022.101604 [Article Type] Research article
Performance and application evaluation of SARS-CoV-2 antigen assaySARS-CoV-2 항원 분석의 성능 및 응용 평가Review Published on 2022-08-012022-09-11 Journal: Journal of medical virology [Category] COVID19(2023년), SARS, 변종, 치료기술, [키워드] Accessibility accumulated acute respiratory syndrome acute respiratory syndrome coronavirus addition alleviate Antigen antigen detection approved Asymptomatic can not Clinical data coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 diagnosis COVID-19 vaccines diagnoses Diagnosis False positive False positives gold gold standard hospitals increase in Interpretation Laboratory laboratory diagnosis mutant mutant strain Mutant strains Negative predictive value nucleic acid Nucleic acid detection offer performance positive result Practitioner Predictive value Prevalence Probability promote reagent SARS-CoV-2 SARS-CoV-2 antigen SARS-COV-2 infection SARS-CoV-2 nucleic acid sensitivity Sensitivity and specificity severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 specificity specificity. speed the SARS-CoV-2 the WHO trade-off WHO [DOI] 10.1002/jmv.27798 PMC 바로가기 [Article Type] Review
Rapid, point-of-care antigen tests for diagnosis of SARS-CoV-2 infectionSARS-CoV-2 감염 진단을 위한 신속한 현장 진료 항원 검사Review Published on 2022-07-222022-09-11 Journal: The Cochrane database of systematic reviews [Category] COVID19(2023년), MERS, SARS, 진단, 치료기술, 치료제, [키워드] 95% CI 95% confidence interval absence access Accuracy age Antigen antigen test antigen tests approach assays Asymptomatic average Bern bioRxiv brand can not carried Chain Reaction Characteristics checked CIs Cohort Compliance conducted COVID-19 COVID-19 pandemic COVID-19 testing criteria criterion Data collection database demonstrated described detect diagnosis of SARS-CoV-2 diagnostic Diagnostic accuracy diagnostic tests Effectiveness eligible epidemiological estimate Europe evaluate evaluated Evidence exposure to False positive False positives global health groups Health Organization healthcare help heterogeneity highest include independent indication Infection Interpretation investigated logistic regression models management Mass screening measure medRxiv molecular test National Open Access Other participant Participants Patient care point-of-care polymerase chain polymerase chain reaction population groups Positive predictive value positive result PPV Predictive value presence or absence Prevalence produced public health QUADAS-2 random-effect ranged Rapid rapid antigen test Rapid antigen tests Rapid diagnostic test reduce reducing reference reference standard Reference standards repeated reported Research respiratory respiratory sample resulting reverse transcription reverse transcription polymerase chain reaction RT-PCR RT-PCR testing SARS-CoV-2 SARS-COV-2 infection Schools screened screening procedure screening programmes searched second Selection sensitivities sensitivity Sensitivity and specificity Seven Signs and symptoms Source Specificities specificity study cohort Study design Symptom symptom onset symptom status symptomatic symptomatic and asymptomatic symptomatic participant symptomatic participants symptomatic people symptoms of COVID-19 test negative test result Testing to define Transmission Triage unique University of Bern variable Viral Viral load viral loads website were used WHO World Health Organization [DOI] 10.1002/14651858.CD013705.pub3 PMC 바로가기 [Article Type] Review
Machine learning to support visual auditing of home-based lateral flow immunoassay self-test results for SARS-CoV-2 antibodies Research Published on 2022-07-062022-10-05 Journal: Communications Medicine [Category] 진단, [키워드] Accuracy Algorithm Analysis antibody Antigen automated Blood Cohen’s kappa Community COVID-19 datasets detect England false negatives False positive false-negative False-positive Flow IgG IgG test immunoassay IMPROVE Interpretation Lateral lateral flow immunoassay Lateral flow test LFIA LFIAs machine performed positive Prevalence prevalence study REACT-2 reducing reported Result risk SARS-CoV-2 antibody sensitivity Sensitivity and specificity Study participants Support Surveillance test line toolkit [DOI] 10.1038/s43856-022-00146-z [Article Type] Research